Schachtele, Christoph: search on Z-Library

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1

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

Thomas Beckers, Andreas Sellmer, Emerich Eichhorn, Herwig Pongratz, Christoph Schächtele, Frank Totzke, Gerhard Kelter, Rebekka Krumbach, Heinz-Herbert Fiebig, Frank-D. Böhmer, Siavosh Mahboobi

Journal:

Bioorganic & Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.30 MB

english, 2012

2

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors

Barbosa, Maria Letícia de Castro, Lima, Lídia Moreira, Tesch, Roberta, Sant'Anna, Carlos Mauricio R., Totzke, Frank, Kubbutat, Michael H.G., Schächtele, Christoph, Laufer, Stefan A., Barreiro, Eliezer

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.34 MB

english, 2014

3

Development of First Lead Structures for Phosphoinositide 3-Kinase-C2γ Inhibitors

Freitag, Anne, Prajwal, Prajwal, Shymanets, Aliaksei, Harteneck, Christian, Nürnberg, Bernd, Schächtele, Christoph, Kubbutat, Michael, Totzke, Frank, Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.49 MB

english, 2015

4

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance

Fischer, Tim, Najjar, Karim, Totzke, Frank, Schächtele, Christoph, Sippl, Wolfgang, Ritter, Christoph, Hilgeroth, Andreas

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.23 MB

english, 2018

5

Structure-Aided Optimization of Kinase Inhibitors Derived from Alsterpaullone

Conrad Kunick, Zhihong Zeng, Rick Gussio, Daniel Zaharevitz, Maryse Leost, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Laurent Meijer, Thomas Lemcke

Journal:

Year:

2005

Language:

english

File:

PDF, 283 KB

english, 2005

6

Probing Novel 1-Aza-9-oxafluorenes as Selective GSK-3β Inhibitors

Burkhardt Voigt, Martin Krug, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth

Journal:

Year:

2008

Language:

english

File:

PDF, 287 KB

english, 2008

7

Discovery of 4-Benzylamino-Substituted α-Carbolines as a Novel Class of Receptor Tyrosine Kinase Inhibitors

Dr. Martin Krug, Dr. Kanin Wichapong, German Erlenkamp, Prof. Dr. Wolfgang Sippl, Dr. Christoph Schächtele, Dr. Frank Totzke, Priv.-Doz. Dr. Andreas Hilgeroth

Journal:

Year:

2011

Language:

english

File:

PDF, 413 KB

english, 2011

8

Synthesis and biological evaluation of an albumin-binding prodrug of doxorubicin that is cleaved by prostate-specific antigen (PSA) in a PSA-positive orthotopic prostate carcinoma model (LNCaP)

Ralph Graeser, Da-Eun Chung, Norbert Esser, Sandra Moor, Christoph Schächtele, Clemens Unger, Felix Kratz

Journal:

International Journal of Cancer

Year:

2008

Language:

english

File:

PDF, 518 KB

english, 2008

9

Identification of Inhibitors of the Tyrosine Kinase c-Met by Structure-Based Virtual Screening

Thomas Lemcke, Jan Dreher, Matthias Rarey, Frank Totzke, Christoph Schächtele, Michael H. G. Kubbutat, Conrad Kunick

Journal:

Molecular Informatics

Year:

2011

Language:

english

File:

PDF, 372 KB

english, 2011

10

Matrix compare analysis discriminates subtle structural differences in a family of novel antiproliferative agents, diaryl-3-hydroxy-2,3,3a,10a-tetrahydrobenzo[b]cycylopenta[e]azepine-4,10(1H,5H)-diones

Conrad Kunick, Carola Bleeker, Christian Prühs, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Andreas Link

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 137 KB

english, 2006

11

N-substituted 2′-(aminoaryl)benzothiazoles as kinase inhibitors: Hit identification and scaffold hopping

Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Rolf Krauss, Frank Totzke, Michael H.G. Kubbutat, Christoph Schächtele

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 3.30 MB

english, 2009

12

Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors

Martin Krug, German Erlenkamp, Wolfgang Sippl, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 527 KB

english, 2010

13

1-Aryl-4,6-dihydropyrazolo[4,3-d][1]benzazepin-5(1H)-ones: A new class of antiproliferative agents with selectivity for human leukemia and breast cancer cell lines

Simone Kohfeld, Peter G. Jones, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 286 KB

english, 2007

14

Design, synthesis and characterization of N9/N7-substituted 6-aminopurines as VEGF-R and EGF-R inhibitors

Christian Peifer, Stefanie Bühler, Dominik Hauser, Katrin Kinkel, Frank Totzke, Christoph Schächtele, Stefan Laufer

Journal:

European Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 264 KB

english, 2009

15

Dual IGF-1R/SRC inhibitors based on a N′-aroyl-2-(1H-indol-3-yl)-2-oxoacetohydrazide structure

Stefanie Schmidt, Lutz Preu, Thomas Lemcke, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 627 KB

english, 2011

16

Mode of glucan degradation by purified phosphorylase forms from spinach leaves

Martin Steup, Christoph Schächtele

Journal:

Year:

1981

Language:

english

File:

PDF, 1.12 MB

english, 1981

17

Purification of a non-chloroplastic α-glucan phosphorylase from spinach leaves

Martin Steup, Christoph Schächtele, Erwin Latzko

Journal:

Year:

1980

Language:

english

File:

PDF, 698 KB

english, 1980

18

Active interaction of human A375 melanoma cells with the lymphatics in vivo

Maria Papoutsi, Gerhard Siemeister, Karin Weindel, Stanislav I. Tomarev, Haymo Kurz, Christoph Schächtele, Georg Martiny-Baron, Bodo Christ, Dieter Marmé, Jörg Wilting

Journal:

Histochemistry and Cell Biology

Year:

2000

Language:

english

File:

PDF, 560 KB

english, 2000

19

Substituted 2-arylbenzothiazoles as kinase inhibitors: Hit-to-lead optimization

Stefan Tasler, Oliver Müller, Tanja Wieber, Thomas Herz, Stefano Pegoraro, Wael Saeb, Martin Lang, Rolf Krauss, Frank Totzke, Ute Zirrgiebel, Jan E. Ehlert, Michael H.G. Kubbutat, Christoph Schächtele

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.58 MB

english, 2009

20

Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes

Burkhardt Voigt, Laurent Meijer, Olivier Lozach, Christoph Schächtele, Frank Totzke, Andreas Hilgeroth

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 256 KB

english, 2005

21

Light-mediated changes in the plastidic phosphorylase patterns in shoots of Pisum sativum

Martin Steup, Christoph Schächtele, Michael Melkonian

Journal:

Physiologia Plantarum

Year:

1986

Language:

english

File:

PDF, 2.00 MB

english, 1986

22

2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

Renate Determann, Jan Dreher, Knut Baumann, Lutz Preu, Peter G. Jones, Frank Totzke, Christoph Schächtele, Michael H.G. Kubbutat, Conrad Kunick

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 646 KB

english, 2012

23

Stereoselective inhibition of calmodulin-dependent cAMP phosphodiesterase from bovine heart by (+)- and (−)-nimodipine

Christoph Schächtele, Bernd Wagner, Dieter Marmé

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1987

Language:

english

File:

PDF, 398 KB

english, 1987

24

Characterization of multiple forms of phosphoinositide-specific phospholipase C from bovine aorta

Michael Späth, Rüdiger Woscholski, Christoph Schächtele

Journal:

Cellular Signalling

Year:

1991

Language:

english

File:

PDF, 394 KB

english, 1991

25

Phosphorylation of the purified receptor for calcium channel blockers by cAMP kinase and protein kinase C

Wolfgang NASTAINCZYK, Axel RÖHRKASTEN, Manfred SIEBER, Claus RUDOLPH, Christophe SCHÄCHTELE, Dieter MARMÈ, Franz HOFMANN

Journal:

Year:

1987

Language:

english

File:

PDF, 772 KB

english, 1987

26

Sites phosphorylated in bovine cardiac troponin T and I : Characterization by 31P-NMR spectroscopy and phosphorylation by protein kinases

Kristine SWIDEREK, Kornelia JAQUET, Helmut E. MEYER, Christoph SCHÄCHTELE, Franz HOFMANN, Ludwig M. G. HEILMEYER Jr

Journal:

Year:

1990

Language:

english

File:

PDF, 795 KB

english, 1990

27

Novel aspects in structure–activity relationships of profiled 1-aza-9-oxafluorenes as inhibitors of Alzheimer's disease-relevant kinases cdk1, cdk5 and gsk3β

Tell, Volkmar, Mahmoud, Kazem Ahmed, Wichapong, Kanin, Schächtele, Christoph, Totzke, Frank, Sippl, Wolfgang, Hilgeroth, Andreas

Journal:

Year:

2012

Language:

english

File:

PDF, 2.30 MB

english, 2012

28

Expression of Biologically Active Isoforms of the Tumor Angiogenesis Factor VEGF inEscherichia coli

Gerhard Siemeister, Bernhard Schnurr, Katja Mohrs, Christoph Schächtele, Dieter Marmé, Georg Martiny-Baron

Journal:

Biochemical and Biophysical Research Communications

Year:

1996

Language:

english

File:

PDF, 6.34 MB

english, 1996

29

Activation of protein kinase C by cis- and trans-octadecadienoic acids in intact human platelets and its potentiation by diacylglycerol

Roland Seifert, Christoph Schächtele, Günter Schultz

Journal:

Biochemical and Biophysical Research Communications

Year:

1987

Language:

english

File:

PDF, 569 KB

english, 1987

30

Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol

Roland Seifert, Christoph Schächtele, Walter Rosenthal, Günter Schultz

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 425 KB

english, 1988

31

Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine

Christoph Schächtele, Roland Seifert, Hartmut Osswald

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 386 KB

english, 1988

32

Evidence that inhibition of phorbol ester-induced superoxide anion formation by cyclosporin a in phagocytes is not mediated by direct inhibition of protein kinase C

Katharina Wenzel-Seifert, Christoph Schächtele, Richard Hummel, Lore Grünbaum, Roland Seifert

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 516 KB

english, 1994

33

Phorbol 12,13-dibutyrate-induced contraction of isolated rabbit vascular smooth muscle

Bernd Wagner, Christoph Schächtele, Dieter Marmé

Journal:

European Journal of Pharmacology

Year:

1987

Language:

english

File:

PDF, 404 KB

english, 1987

34

Effect of Ca2+ entry blockers on myosin light-chain kinase and protein kinase C

Christoph Schächtele, Bernd Wagner, Claus Rudolph

Journal:

European Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 303 KB

english, 1989

35

Synthetic diacylglycerols induce a rise of quin2-detectable free intracellular calcium in human platelets

Christian Bruns, Christoph Schächtele, Dieter Marmé

Journal:

Year:

1987

Language:

english

File:

PDF, 428 KB

english, 1987

36

Studies with protein kinase C inhibitors presently available cannot elucidate the role of protein kinase C in the activation of NADPH oxidase

Roland Seifert, Christoph Schächtele

Journal:

Biochemical and Biophysical Research Communications

Year:

1988

Language:

english

File:

PDF, 412 KB

english, 1988

37

Assessing the Target Differentiation Potential of Imidazole-Based Protein Kinase Inhibitors

Dimova, Dilyana, Iyer, Preeti, Vogt, Martin, Totzke, Frank, Kubbutat, Michael H. G., Schächtele, Christoph, Laufer, Stefan, Bajorath, Jürgen

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 622 KB

english, 2012

38

Novel indolocarbazole protein kinase C inhibitors prevent reactivation of HIV-1 in latently infected cells

Susanne Pätzold, Josef Schneider, Claus Rudolph, Dieter Marme, Christoph Schächtele

Journal:

Antiviral Research

Year:

1993

Language:

english

File:

PDF, 627 KB

english, 1993

39

Bis(1 H -2-indolyl)methanones as a Novel Class of Inhibitors of the Platelet-Derived Growth Factor Receptor Kinase

Mahboobi, Siavosh, Teller, Steffen, Pongratz, Herwig, Hufsky, Harald, Sellmer, Andreas, Botzki, Alexander, Uecker, Andrea, Beckers, Thomas, Baasner, Silke, Schächtele, Christoph, Überall, Florian, Kas

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 391 KB

english, 2002

40

Tri- and Tetrasubstituted Pyrazole Derivates: Regioisomerism Switches Activity from p38MAP Kinase to Important Cancer Kinases

Thaher, Bassam Abu, Arnsmann, Martina, Totzke, Frank, Ehlert, Jan E., Kubbutat, Michael H. G., Schächtele, Christoph, Zimmermann, Markus O., Koch, Pierre, Boeckler, Frank M., Laufer, Stefan A.

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.82 MB

english, 2012

41

Design, Synthesis, and Biological Evaluation of 3,4-Diarylmaleimides as Angiogenesis Inhibitors

Peifer, Christian, Stoiber, Thomas, Unger, Eberhard, Totzke, Frank, Schächtele, Christoph, Marmé, Dieter, Brenk, Ruth, Klebe, Gerhard, Schollmeyer, Dieter, Dannhardt, Gerd

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 482 KB

english, 2006

42

Evaluation of the First Cytostatically Active 1-Aza-9-oxafluorenes as Novel Selective CDK1 Inhibitors with P-Glycoprotein Modulating Properties

Brachwitz, Kristin, Voigt, Burkhardt, Meijer, Laurent, Lozach, Olivier, Schächtele, Christoph, Molnár, Josef, Hilgeroth, Andreas

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 51 KB

english, 2003

43

Profile and Molecular Modeling of 3-(Indole-3-yl)-4-(3,4,5-trimethoxyphenyl)-1 H -pyrrole-2,5dione ( 1 ) as a Highly Selective VEGF-R2/3 Inhibitor

Peifer, Christian, Krasowski, Agata, Hämmerle, Nina, Kohlbacher, Oliver, Dannhardt, Gerd, Totzke, Frank, Schächtele, Christoph, Laufer, Stefan

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 426 KB

english, 2006

44

Novel inhibitors of breast cancer relevant kinases Brk and HER2

Mahmoud, Kazem Ahmed, Wersig, Tom, Slynko, Inna, Totzke, Frank, Schächtele, Christoph, Oelze, Markus, Sippl, Wolfgang, Ritter, Christoph, Hilgeroth, Andreas

Journal:

Year:

2014

Language:

english

File:

PDF, 393 KB

english, 2014

45

Discovery of 4-anilino α-carbolines as novel Brk inhibitors

Mahmoud, Kazem Ahmed, Krug, Martin, Wersig, Tom, Slynko, Inna, Schächtele, Christoph, Totzke, Frank, Sippl, Wolfgang, Hilgeroth, Andreas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 518 KB

english, 2014

46

Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases

Tell, Volkmar, Holzer, Max, Herrmann, Lydia, Mahmoud, Kazem Ahmed, Schächtele, Christoph, Totzke, Frank, Hilgeroth, Andreas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 417 KB

english, 2012

47

Vacancies.

Tell, Volkmar, Holzer, Max, Herrmann, Lydia, Mahmoud, Kazem Ahmed, Schächtele, Christoph, Totzke, Frank, Hilgeroth, Andreas

Journal:

Year:

1895

Language:

english

File:

PDF, 205 KB

english, 1895

48

Separation and Partial Characterization of Chloroplast and Non-chloroplast a-Glucan Phosphorylases from Spinach Leaves

Steup, Martin, Schachtele, Christoph, Latzko, Erwin

Journal:

Zeitschrift für Pflanzenphysiologie

Year:

1980

Language:

english

File:

PDF, 555 KB

english, 1980

49

Non-chloroplast α-1,4-glucan phosphorylase from pea leaves: characterization and in situ localization by indirect immunofluorescence

Conrads, Jutta, van Berkel, Joachim, Schächtele, Christoph, Steup, Martin

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

1986

Language:

english

File:

PDF, 1.02 MB

english, 1986

50

Optimization of Potent DFG-in Inhibitors of Platelet Derived Growth Factor Receptorβ (PDGF-Rβ) Guided by Water Thermodynamics

Horbert, Rebecca, Pinchuk, Boris, Johannes, Eugen, Schlosser, Joachim, Schmidt, Dorian, Cappel, Daniel, Totzke, Frank, Schächtele, Christoph, Peifer, Christian

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 5.73 MB

english, 2015